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KMID : 0369820010310040257
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Jorunal of Korean Pharmaceutical Sciences
2001 Volume.31 No. 4 p.257 ~ p.263
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Comparative Study of Spray Drying Method and Solvent Evaporation Method for Preparation of Biodegradable Microspheres Containing Nicotine and Triamcinolone Acetonide
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박선영/Park SY
조미현/이종화/김동우/지웅길/Cho MH/Leek JH/Kim DW/Lee UK
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Abstract
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The microspheres have been developed as a new drug delivery system. Although many particulate drug carriers, such as liposome, niosome and emulsion, have been introduced, injectable and biodegradable microspheres appears to be a particularly ideal delivery system because the local anesthesia is not necessary for the insertion of large implants and for the removal of the device after the drug release is finished. Biodegradable microspheres with nicotine and triamcinolone acetonide are prepared and evaluated. As biodegradible polymers, PLA (M.W. 15,000, PLA-0015), PLGA (M.W. 17,000, RG 502) and PLGA (M.W. 8,600, RG 502H) are used. This study attempted to prepare and evaluate the nicotine and triamcinolone acetonide-incorporated microspheres, which were prepared by two methods, solvent-evaporation and spray-drying methods. The microspheres, as a disperse system for injections, were evaluated by particle size, size distribution, entrapment efficiency, and in vitro drug release patterns. The differences of preparation method, partition coefficient, types of polymer, and preparation conditions of microspheres influence the particle size, entrapment efficiency, and in vitro drug release patterns.
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KEYWORD
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Microsphere, PLA, PLGA, Solvent-evaporation, Spray-drying
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